Pyrvinium

Pyrvinium
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	P02CX01 (WHO) ;
Identifiers
	IUPAC name 2-[(E)-2-(2,5-Dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine;
CAS Number	7187-62-4;
PubChem CID	5281035;
ChemSpider	21125;
UNII	6B9991FLU3;
KEGG	C07412;
ChEBI	CHEBI:8687;
ChEMBL	ChEMBL1201303;
CompTox Dashboard (EPA)	DTXSID4023545 ;
ECHA InfoCard	100.020.543
Chemical and physical data
Formula	C26H28N3+
Molar mass	382.531 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=C(N1C2=CC=CC=C2)C)/C=C/C3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C;
	InChI InChI=1S/C26H28N3/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5/h6-18H,1-5H3/q+1; Key:QMHSXPLYMTVAMK-UHFFFAOYSA-N;

Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α.

Pyrvinium salts can also inhibit the growth of cancer cells. More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation.

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