Protein O-GlcNAcase

OGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YDQ
Identifiers
Aliases	OGA, MEA5, NCOAT, meningioma expressed antigen 5 (hyaluronidase), MGEA5, O-GlcNAcase
External IDs	OMIM: 604039 MGI: 1932139 HomoloGene: 8154 GeneCards: OGA
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,818,465 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,772,276 bp
RNA expression pattern
	Top expressed in
	sperm; ; skin of abdomen; ; cerebellar hemisphere; ; tibial nerve; ; right uterine tube; ; gastric mucosa; ; ganglionic eminence; ; Achilles tendon; ; canal of the cervix; ; right coronary artery;
	Top expressed in
	saccule; ; otic placode; ; fossa; ; conjunctival fornix; ; motor neuron; ; ciliary body; ; condyle; ; medullary collecting duct; ; substantia nigra; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hyalurononglucosaminidase activity; beta-N-acetylglucosaminidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; [protein-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity]; [protein-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity]; [protein-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity];
Cellular component	cytoplasm; cytosol; membrane; nucleus;
Biological process	metabolism; protein deglycosylation; N-acetylglucosamine metabolic process; glycoprotein catabolic process; protein O-linked glycosylation; glycoprotein metabolic process; viral process;
	Sources:Amigo / QuickGO
Orthologs
	10724
	76055
	ENSG00000198408
	ENSMUSG00000025220
	O60502
	Q9EQQ9
	NM_001142434; NM_012215
	NM_023799
	NP_001135906; NP_036347
	NP_076288
	Wikidata
View/Edit Human	View/Edit Mouse

Protein O-GlcNAcase (EC 3.2.1.169, OGA, glycoside hydrolase O-GlcNAcase, O-GlcNAcase, BtGH84, O-GlcNAc hydrolase) is an enzyme with systematic name (protein)-3-O-(N-acetyl-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase. OGA is encoded by the OGA gene. This enzyme catalyses the removal of the O-GlcNAc post-translational modification in the following chemical reaction:

[protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-serine + H₂O ⇌ [protein]-L-serine + N-acetyl-D-glucosamine
[protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-threonine + H₂O ⇌ [protein]-L-threonine + N-acetyl-D-glucosamine

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