Glutamate carboxypeptidase II

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glutamate carboxypeptidase II
glutamate carboxypeptidase II
	Reaction Scheme of NAAG Degradation by GCPII: GCPII + NAAG → GCPII-NAAG complex → Glutamate + NAA
Identifiers
EC no.	3.4.17.21
CAS no.	111070-04-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

FOLH1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4P4J, 1Z8L, 2C6C, 2C6G, 2C6P, 2CIJ, 2JBJ, 2JBK, 2OOT, 2OR4, 2PVV, 2PVW, 2XEF, 2XEG, 2XEI, 2XEJ, 3BHX, 3BI0, 3BI1, 3BXM, 3D7D, 3D7F, 3D7G, 3D7H, 3IWW, 3RBU, 3SJE, 3SJF, 3SJG, 3SJX, 4JYW, 4JZ0, 4LQG, 4MCP, 4MCQ, 4MCR, 4MCS, 4NGM, 4NGN, 4NGP, 4NGQ, 4NGR, 4NGS, 4NGT, 4OC0, 4OC1, 4OC2, 4OC3, 4OC4, 4OC5, 4OME, 4P44, 4P45, 4P4B, 4P4D, 4P4E, 4P4F, 4P4I, 4W9Y, 4X3R, 5F09, 5D29, 5ELY
Identifiers
Aliases	FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, folate hydrolase (prostate-specific membrane antigen) 1, folate hydrolase 1
External IDs	OMIM: 600934 HomoloGene: 136782 GeneCards: FOLH1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	49,208,638 bp
RNA expression pattern
	Top expressed in
	duodenum; ; corpus callosum; ; substantia nigra; ; hippocampus proper; ; putamen; ; prostate; ; amygdala; ; liver; ; gallbladder; ; caudate nucleus;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; tetrahydrofolyl-poly(glutamate) polymer binding; peptidase activity; catalytic activity; metallocarboxypeptidase activity; carboxypeptidase activity; Ac-Asp-Glu binding; hydrolase activity; metallopeptidase activity; dipeptidase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome;
Biological process	cellular amino acid biosynthetic process; proteolysis; C-terminal protein deglutamylation; metabolism; folic acid-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2346
	n/a
	ENSG00000086205
	n/a
	Q04609
	n/a
NM_001014986; NM_001193471; NM_001193472; NM_001193473; NM_004476;
	NM_001351236
	n/a
NP_001014986; NP_001180400; NP_001180401; NP_001180402; NP_004467;
	NP_001338165
	n/a
	Wikidata
View/Edit Human

Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately 84 kDa.

GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) according to the reaction scheme to the right.

Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All refer to the same protein glutamate carboxypeptidase II.

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