Propylthiouracil

Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. In a thyrotoxic crisis it is generally more effective than methimazole. Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible. It is taken by mouth.

Propylthiouracil
Clinical data
Other names6-n-propylthiouracil (PROP)
AHFS/Drugs.comMonograph
MedlinePlusa682465
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • US: WARNING
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability80%-95%
Metabolism?
Elimination half-life2 hours
Excretion?
Identifiers
  • 6-propyl-2-sulfanylpyrimidin-4-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.095
Chemical and physical data
FormulaC7H10N2OS
Molar mass170.23 g·mol−1
3D model (JSmol)
Melting point219 to 221 °C (426 to 430 °F)
  • S=C1N/C(=C\C(=O)N1)CCC
  • InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11) Y
  • Key:KNAHARQHSZJURB-UHFFFAOYSA-N Y
  (verify)

Common side effects include itchiness, hair loss, parotid swelling, vomiting, muscle pains, numbness, and headache. Other severe side effects include liver problems and low blood cell counts. Use during pregnancy may harm the baby. Propylthiouracil is in the antithyroid family of medications. It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3).

Propylthiouracil came into medical use in the 1940s. It is on the World Health Organization's List of Essential Medicines.

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