Properdin

CFP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W0R, 1W0S
Identifiers
Aliases	CFP, BFD, PFC, PFD, PROPERDIN, complement factor properdin, properdin
External IDs	OMIM: 300383 MGI: 97545 HomoloGene: 1969 GeneCards: CFP
Gene location (Human)
Chr.	X chromosome (human)
End	47,630,305 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,797,794 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; lymph node; ; right lung; ; liver; ; right lobe of liver;
	Top expressed in
	spleen; ; ankle joint; ; right lobe of liver; ; axillary lymph node; ; white adipose tissue; ; thymus; ; lip; ; subcutaneous adipose tissue; ; blood; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; serine-type endopeptidase activity;
Cellular component	extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space; specific granule lumen; tertiary granule lumen; collagen-containing extracellular matrix;
Biological process	immune response; regulation of complement activation; defense response to bacterium; immune system process; complement activation; protein O-linked fucosylation; complement activation, alternative pathway; innate immune response; neutrophil degranulation; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	5199
	18636
	ENSG00000126759
	ENSMUSG00000001128
	P27918
	P11680
	NM_002621; NM_001145252
	NM_008823
	NP_001138724; NP_002612
	NP_032849
	Wikidata
View/Edit Human	View/Edit Mouse

Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.

Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and C5-convertase enzyme complexes to form an attack complex that lead to the lysis of the cell.

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