Granulin
Granulin is a protein that in humans is encoded by the GRN gene. Each granulin protein is cleaved from the precursor progranulin, a 593 amino-acid-long and 68.5 kDa protein. While the function of progranulin and granulin have yet to be determined, both forms of the protein have been implicated in development, inflammation, cell proliferation and protein homeostasis. The 2006 discovery of the GRN mutation in a population of patients with frontotemporal dementia has spurred much research in uncovering the function and involvement in disease of progranulin in the body. While there is a growing body of research on progranulin's role in the body, studies on specific granulin residues are still limited.
| Granulin | |||||||||
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The solution structure of a well-folded peptide based on the 31-residue amino-terminal subdomain of human granulin a | |||||||||
| Identifiers | |||||||||
| Symbol | Granulin | ||||||||
| Pfam | PF00396 | ||||||||
| InterPro | IPR000118 | ||||||||
| PROSITE | PDOC00634 | ||||||||
| SCOP2 | 1pcn / SCOPe / SUPFAM | ||||||||
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