Procarbazine

Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers. For Hodgkin's it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth.

Procarbazine
Clinical data
Trade namesMatulane, Natulan, Indicarb, others
AHFS/Drugs.comMonograph
MedlinePlusa682094
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (gel capsule), intravenous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolismliver, kidney
Elimination half-life10 minutes
Excretionkidney
Identifiers
  • N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.531
Chemical and physical data
FormulaC12H19N3O
Molar mass221.304 g·mol−1
3D model (JSmol)
  • O=C(c1ccc(cc1)CNNC)NC(C)C
  • InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16) Y
  • Key:CPTBDICYNRMXFX-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

Common side effect include low blood cell counts and vomiting. Other side effects include tiredness and depression. It is not recommended in people with severe liver or kidney problems. Use in pregnancy is known to harm the baby. Procarbazine is in the alkylating agents family of medication. How it works is not clearly known.

Procarbazine was approved for medical use in the United States in 1969. It is on the World Health Organization's List of Essential Medicines. In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds.

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