Pristinamycin IIA

Pristinamycin IIA
Clinical data
Other names	Mikamycin A; Virginiamycin M1
Identifiers
	IUPAC name 8,9,14,15,24,25-Hexahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)(3R,4R,5E,10E,12E,14S)-3H-21,18-nitrolo-1H,22H-pyrrolo\[2,1-c] [1,8,4,19]-dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone;
CAS Number	21411-53-0 ;
PubChem CID	5354042;
ChemSpider	10222381;
UNII	8W4UOL59AZ;
ChEBI	CHEBI:9997 ;
CompTox Dashboard (EPA)	DTXSID30873800 ;
Chemical and physical data
Formula	C28H35N3O7
Molar mass	525.602 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)Cc2nc(co2)C(=O)N3CCC=C3C(=O)O[C@@H]1C(C)C)O)/C;
	InChI InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1; Key:DAIKHDNSXMZDCU-FQTGFAPKSA-N;
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Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being pristinamycin IA). Pristinamycin IIA was first isolated from the Streptomyces virginiae, but has been isolated from other microorganisms and thus has been given a variety of other names such as Virginiamycin M1, Mikamycin A, and Streptogramin A. Pristinamycin IIA structure was determined by chemical and instrumental techniques, including X-ray crystallography. Pristinamycin IIA is of interest from a biosynthetic viewpoint because it contains the unusual dehydroproline and oxazole ring systems. The only experimental evidence bearing on the formation of the oxazole ring is found in work on the biosynthesis of the alkaloid annuloline.

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