Position weight matrix

A position weight matrix (PWM), also known as a position-specific weight matrix (PSWM) or position-specific scoring matrix (PSSM), is a commonly used representation of motifs (patterns) in biological sequences.

This article is about Bioinformatics. For the disease in horses known by the acronym "PSSM", see Equine polysaccharide storage myopathy.

PWMs are often derived from a set of aligned sequences that are thought to be functionally related and have become an important part of many software tools for computational motif discovery.

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