Posaconazole

Posaconazole
Clinical data
Trade names	Noxafil, Posanol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a607036
License data	EU EMA: by INN; US DailyMed: Posaconazole; US FDA: Posaconazole;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth, intravenous
ATC code	J02AC04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	Low (8 to 47% Oral)
Protein binding	98 to 99%
Metabolism	Liver (glucuronidation)
Elimination half-life	16 to 31 hours
Excretion	Fecal (71–77%) and Kidney (13–14%)
Identifiers
	IUPAC name 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2- hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;
CAS Number	171228-49-2 ;
PubChem CID	147912;
DrugBank	DB01263 ;
ChemSpider	130409 ;
UNII	6TK1G07BHZ;
KEGG	D02555 ;
ChEBI	CHEBI:64355 ;
ChEMBL	ChEMBL1397 ;
CompTox Dashboard (EPA)	DTXSID6049066 ;
ECHA InfoCard	100.208.201
Chemical and physical data
Formula	C37H42F2N8O4
Molar mass	700.792 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(/N=C\N1c2ccc(cc2)N7CCN(c6ccc(OCC3C[C@@](OC3)(c4ccc(F)cc4F)Cn5ncnc5)cc6)CC7)[C@@H](CC)[C@@H](O)C;
	InChI InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27?,35-,37-/m0/s1 ; Key:RAGOYPUPXAKGKH-AGDNISCASA-N ;
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Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication.

It was approved for medical use in the United States in September 2006, and is available as a generic medication.

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