Polyestriol phosphate

Polyestriol phosphate (PE3P, SEP), sold under the brand names Gynäsan, Klimadurin, and Triodurin, is an estrogen medication which was previously used in menopausal hormone therapy (i.e., to treat menopausal symptoms in postmenopausal women) and is no longer available.

Not to be confused with Polyestradiol phosphate.
Polyestriol phosphate
Skeletal structure of polyestriol phosphate (top) and ball-and-stick model of estriol phosphate (one monomer of polyestriol phosphate) (bottom)
Clinical data
Trade namesGynäsan, Klimadurin, Triodurin
Other namesPE3P; SEP; Poly(estriol phosphate); Estriol phosphate polymer; Estriol polymer with phosphoric acid
Routes of
administration		Intramuscular injection
Drug classEstrogen; Estrogen ester
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityIM: High
MetabolitesEstriol, phosphoric acid, and metabolites of estriol
ExcretionUrine (as conjugates)
Identifiers
  • Estra-1,3,5(10)-triene-3,16α,17β-triol, polymer with phosphoric acid
CAS Number
UNII
Chemical and physical data
Formula(C18H23O5P)n
(n = variable)
Molar massPolymer: Variable
Repeat unit: 350.346 g/mol
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