Polycythemia vera
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm (chronic leukemia) in which the bone marrow makes too many red blood cells as well as white blood cells and platelets. The majority of cases are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
| Polycythemia vera | |
|---|---|
| Other names | Polycythaemia vera (PV, PCV), erythremia, primary polycythemia, Vaquez disease, Osler-Vaquez disease, polycythemia rubra vera |
| Blood smear from a patient with polycythemia vera | |
| Specialty | Oncology, hematology |
Most of the health concerns associated with polycythemia vera are caused by the blood being thicker as a result of the increased red blood cells. It is more common in the elderly and may be symptomatic or asymptomatic. Common signs and symptoms include itching (pruritus), and severe burning pain in the hands or feet that is usually accompanied by a reddish or bluish coloration of the skin. Patients with polycythemia vera are more likely to have gouty arthritis. Treatment consists primarily of phlebotomy as well as oral chemotherapy and emerging treatments like long-acting interferon formulations.