Polysubstance use

Polysubstance use or poly drug use refers to the use of combined psychoactive substances. Polysubstance use may be used for entheogenic, recreational, or off-label indications, with both legal and illegal substances. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects, or tolerance, of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.

Not to be confused with Polysubstance dependence.
Polysubstance use
Caffeinated alcoholic beverages, such as these caffè corretto cocktails based on espresso and liquor are widespread and legal.
SpecialtyPsychiatry
ComplicationsCombined drug intoxication, drug overdose
Not to be confused with Polysubstance abuse.
For combination of pharmaceuticals, see Combination drug and Polypharmacy.
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