PABPC1

PABPC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02, 4F25, 4F26, 5DX1, 5DXA, 5DX8, 2D9P
Identifiers
Aliases	PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
External IDs	OMIM: 604679 MGI: 1349722 HomoloGene: 37638 GeneCards: PABPC1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	100,722,809 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	36,609,912 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; pylorus; ; amniotic fluid; ; vulva; ; thymus; ; nipple; ; spongy bone; ; monocyte; ; cavity of mouth; ; urethra;
	Top expressed in
	yolk sac; ; spermatocyte; ; morula; ; spermatid; ; lip; ; superior frontal gyrus; ; thymus; ; medullary collecting duct; ; lens; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; nucleic acid binding; protein C-terminus binding; translation activator activity; poly(U) RNA binding; poly(A) binding; mRNA 3'-UTR binding; RNA binding; mRNA binding;
Cellular component	focal adhesion; catalytic step 2 spliceosome; cytoplasmic stress granule; cytoplasm; cytoplasmic ribonucleoprotein granule; spliceosomal complex; membrane; extracellular exosome; nucleus; cytosol; dendrite; ribonucleoprotein granule; synapse; messenger ribonucleoprotein complex; ribonucleoprotein complex;
Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA stabilization; mRNA splicing, via spliceosome; regulation of mRNA stability; RNA splicing; mRNA polyadenylation; mRNA processing; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of viral genome replication; translational initiation; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; gene silencing; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
	Sources:Amigo / QuickGO
Orthologs
	26986
	18458
	ENSG00000070756
	ENSMUSG00000022283
	P11940
	P29341
	NM_002568
	NM_008774
	NP_002559
	NP_032800
	Wikidata
View/Edit Human	View/Edit Mouse

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability. There are two separate PABP1 proteins, one which is located in the nucleus (PABPN1) and the other which is found in the cytoplasm (PABPC1). The location of PABP1 affects the role of that protein and its function with RNA.

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