BPIFA1

BPIFA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KEG, 4KGH, 4KGO, 4N4X, 5I7K, 5I7J, 5I7L
Identifiers
Aliases	BPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, BPI fold containing family A member 1
External IDs	OMIM: 607412 MGI: 1338036 HomoloGene: 7895 GeneCards: BPIFA1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,243,311 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	153,991,139 bp
RNA expression pattern
	Top expressed in
	trachea; ; bronchus; ; bronchial epithelial cell; ; tongue; ; superior surface of tongue; ; body of tongue; ; anterior pituitary; ; cavity of mouth; ; lung; ; thymus;
	Top expressed in
	trachea; ; olfactory epithelium; ; right lung; ; right lung lobe; ; median eminence; ; extraocular muscle; ; cochlea; ; sexually immature organism; ; thymus; ; aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; protein binding; molecular function;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of single-species biofilm formation in or on host organism; multicellular organismal water homeostasis; defense response to bacterium; regulation of sodium ion transmembrane transport; antibacterial humoral response; immune system process; innate immune response; antimicrobial humoral response; regulation of liquid surface tension; immune response in nasopharyngeal-associated lymphoid tissue; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	51297
	18843
	ENSG00000198183
	ENSMUSG00000027483
	Q9NP55
	P97361
	NM_001243193; NM_016583; NM_130852
	NM_011126
	NP_001230122; NP_057667; NP_570913
	NP_035256
	Wikidata
View/Edit Human	View/Edit Mouse

BPI fold containing family A, member 1 (BPIFA1), also known as Palate, lung, and nasal epithelium clone (PLUNC), is a protein that in humans is encoded by the BPIFA1 gene. It was also formerly known as "Secretory protein in upper respiratory tracts" (SPURT). The BPIFA1 gene sequence predicts 4 transcripts (splice variants); 3 mRNA variants have been well characterized. The resulting BPIFA1 is a secreted protein, expressed at very high levels in mucosa of the airways (olfactory and respiratory and epithelium) and salivary glands; at high levels in oropharyneal epithelium, including tongue and tonsils; and at moderate levels many other tissue types and glands including pituitary, testis, lung, bladder, blood, prostate, pancreas, levels in the digestive tract (tongue, stomach, intestinal epithelium) and pancreas. The protein can be detected on the apical side of epithelial cells and in airway surface liquid, nasal mucus, and sputum.

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