Plakoglobin

JUP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IFQ
Identifiers
Aliases	JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG
External IDs	OMIM: 173325 MGI: 96650 HomoloGene: 1680 GeneCards: JUP
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,786,931 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,288,589 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; nipple; ; human penis; ; vulva; ; body of tongue; ; cavity of mouth; ; minor salivary gland; ; renal medulla; ; right uterine tube; ; left ventricle;
	Top expressed in
	lip; ; esophagus; ; corneal stroma; ; skin of back; ; stomach; ; pyloric antrum; ; epithelium of stomach; ; yolk sac; ; skin of abdomen; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; transcription coactivator activity; structural constituent of cell wall; structural molecule activity; signal transducer activity; protein binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; protein phosphatase binding; protein kinase binding; alpha-catenin binding; cell adhesion molecule binding; cadherin binding;
Cellular component	cytoplasm; cytosol; gamma-catenin-TCF7L2 complex; lateral plasma membrane; membrane; intercalated disc; cell-cell junction; focal adhesion; adherens junction; plasma membrane; desmosome; hemidesmosome; cell junction; apicolateral plasma membrane; protein-DNA complex; Z disc; actin cytoskeleton; zonula adherens; cytoplasmic side of plasma membrane; catenin complex; fascia adherens; cytoskeleton; intermediate filament; extracellular exosome; nucleus; extracellular matrix; cornified envelope; extracellular region; specific granule lumen; ficolin-1-rich granule lumen;
Biological process	adherens junction assembly; protein heterooligomerization; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA-binding transcription factor activity; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; endothelial cell-cell adhesion; cellular response to indole-3-methanol; desmosome assembly; cell adhesion; regulation of cell population proliferation; detection of mechanical stimulus; positive regulation of protein import into nucleus; adherens junction organization; regulation of heart rate by cardiac conduction; cell migration; regulation of ventricular cardiac muscle cell action potential; skin development; signal transduction; keratinization; neutrophil degranulation; cornification; protein localization to plasma membrane; cell-cell adhesion; positive regulation of cell-matrix adhesion; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3728
	16480
	ENSG00000173801
	ENSMUSG00000001552
	P14923
	Q02257
NM_002230; NM_021991; NM_001352773; NM_001352774; NM_001352775;
	NM_001352776; NM_001352777
	NM_010593
NP_002221; NP_068831; NP_001339702; NP_001339703; NP_001339704;
	NP_001339705; NP_001339706
	NP_034723
	Wikidata
View/Edit Human	View/Edit Mouse

Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia.

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