Pitavastatin

Pitavastatin
Clinical data
Trade names	Livalo, Livazo, others
AHFS/Drugs.com	Monograph
MedlinePlus	a610018
License data	US FDA: Pitavastatin;
Pregnancy; category	AU: D;
Routes of; administration	By mouth (tablets)
ATC code	C10AA08 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	60%
Protein binding	96%
Metabolism	Liver (CYP2C9, minimally)
Elimination half-life	11 hours
Excretion	Faeces
Identifiers
	IUPAC name (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid;
CAS Number	147511-69-1 ;
PubChem CID	5282452;
IUPHAR/BPS	3035;
ChemSpider	4445604 ;
UNII	M5681Q5F9P;
ChEBI	CHEBI:32020 ;
ChEMBL	ChEMBL1201753 ;
CompTox Dashboard (EPA)	DTXSID1048384 ;
ECHA InfoCard	100.171.153
Chemical and physical data
Formula	C25H24FNO4
Molar mass	421.461 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C[C@H](O)C[C@H](O)/C=C/c1c(c3ccccc3nc1C2CC2)c4ccc(F)cc4;
	InChI InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1 ; Key:VGYFMXBACGZSIL-MCBHFWOFSA-N ;
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Pitavastatin (usually as a calcium salt) is a member of the blood cholesterol lowering medication class of statins.

Like other statins, it is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of cholesterol synthesis.

It was patented in 1987 and approved for medical use in 2003. It is available in Japan, South Korea and in India. In the US, it received FDA approval in 2009. Kowa Pharmaceuticals, a subsidiary of Kowa Company, is the owner of the American patent to pitavastatin.

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