Pituitary-specific positive transcription factor 1

POU1F1
Identifiers
Aliases	POU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDs	OMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	87,276,584 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	65,331,891 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; striated muscle tissue; ; skeletal muscle tissue; ; gastrocnemius muscle; ; Brodmann area 9; ; right uterine tube; ; right coronary artery; ; gallbladder; ; prefrontal cortex;
	Top expressed in
	female urethra; ; anterior pituitary; ; bone marrow; ; duodenum; ; urinary bladder; ; ovary;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; transcription corepressor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; DNA-binding transcription factor activity; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex; chromatin;
Biological process	negative regulation of cell population proliferation; somatotropin secreting cell development; adenohypophysis development; positive regulation of inositol trisphosphate biosynthetic process; regulation of insulin-like growth factor receptor signaling pathway; pituitary gland development; regulation of transcription, DNA-templated; cell fate specification; B cell differentiation; positive regulation of cell population proliferation; positive regulation of transcription, DNA-templated; determination of adult lifespan; positive regulation of transcription by RNA polymerase II; positive regulation of multicellular organism growth; nuclear transport; negative regulation of transcription by RNA polymerase II; somatotropin secreting cell differentiation; transcription, DNA-templated; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5449
	18736
	ENSG00000064835
	ENSMUSG00000004842
	P28069
	Q00286
	NM_001122757; NM_000306
	NM_008849; NM_001362468
	NP_000297; NP_001116229
	NP_032875; NP_001349397
	Wikidata
View/Edit Human	View/Edit Mouse

POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for growth hormone encoded by the gene POU1F1.

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