Tenosynovial giant cell tumor

Tenosynovial giant cell tumor (TGCT) is a group of rare, typically non-malignant tumors of the joints. TGCT tumors often develop from the lining of joints (also known as synovial tissue).: 100 : 245 

"TGCT" redirects here. For testicular germ cell tumor, see Germ cell tumor.
Tenosynovial giant cell tumor
Other namesLocalized: Localized pigmented villonodular synovitis (L-PVNS), Giant cell tumor of the tendon sheath (GCT-TS), Nodular tenosynovitis, Localized nodular tenosynovitis, and L-TGCT
Diffuse: Pigmented villonodular synovitis (PVNS), Conventional PVNS, and D-TGCT
Micrograph of diffuse TGCT, also known as pigmented villonodular synovitis. H&E stain.
SpecialtyRheumatology
SymptomsSwelling, pain, sensitivity, and/or limited range of motion
ComplicationsSpreading of tumors to surrounding tissues
TypesDiffuse and localized
Diagnostic methodMRI, biopsy, surgery
TreatmentSurgery, CSF1R inhibitors

Common symptoms of TGCT include swelling, pain, stiffness and reduced mobility in the affected joint or limb.: 102  This group of tumors can be divided into different subsets according to their site, growth pattern, and prognosis.: 361  Localized TGCT is sometimes referred to as giant cell tumor of the tendon sheath;: 100  diffuse TGCT is also called pigmented villonodular synovitis (PVNS).: 102 

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