Phospholipase A1
Phospholipase A1 (EC 3.1.1.32; systematic name: phosphatidylcholine 1-acylhydrolase) encoded by the PLA1A gene is a phospholipase enzyme which removes the 1-acyl group:
- phosphatidylcholine + H2O ⇌ 2-acylglycerophosphocholine + a carboxylate
Crystallographic structure of phospholipase A1. Red region denotes α helices, Green region denotes loops, and yellow region denotes β sheets. | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| EC no. | 3.1.1.32 | ||||||||
| CAS no. | 9043-29-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| phospholipase A1 member A | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PLA1A | ||||||
| NCBI gene | 51365 | ||||||
| HGNC | 17661 | ||||||
| OMIM | 607460 | ||||||
| RefSeq | NM_015900 | ||||||
| UniProt | Q53H76 | ||||||
| Other data | |||||||
| EC number | 3.1.1.32 | ||||||
| Locus | Chr. 3 q13.13-13.2 | ||||||
| |||||||
It is an enzyme that resides in a class of enzymes called phospholipase that hydrolyze phospholipids into fatty acids. There are four classes, separated according to the type of reaction they catalyze. In particular, phospholipase A1 (PLA1) specifically catalyzes the cleavage at the sn-1 position of phospholipids, forming a fatty acid and a lysophospholipid.
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