Phenylthiocarbamide

Phenylthiocarbamide (PTC), also known as phenylthiourea (PTU), is an organosulfur thiourea containing a phenyl ring.

Phenylthiocarbamide
Names
Preferred IUPAC name
Phenylthiourea
Other names
N-Phenylthiourea
1-Phenylthiourea
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.002.865
MeSH Phenylthiourea
UNII
  • InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10) N
    Key: FULZLIGZKMKICU-UHFFFAOYSA-N N
  • InChI=1/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
    Key: FULZLIGZKMKICU-UHFFFAOYAW
  • C1=CC=C(C=C1)NC(=S)N
Properties
C7H8N2S
Molar mass 152.22 g·mol−1
Appearance White to slightly yellow powder
Density 1.294 g/cm3
Melting point 145 to 150 °C (293 to 302 °F; 418 to 423 K)
Soluble in boiling water
Hazards
GHS labelling:
Danger
H300, H317
P280, P301+P310+P330, P302+P352
NFPA 704 (fire diamond)
4
1
0
Lethal dose or concentration (LD, LC):
3 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

It has the unusual property that it either tastes very bitter or is virtually tasteless, depending on the genetic makeup of the taster. The ability to taste PTC is often treated as a dominant genetic trait, although inheritance and expression of this trait are somewhat more complex.

PTC also inhibits melanogenesis and is used to grow transparent fish.

About 70% of people can taste PTC, varying from a low of 58% for Indigenous Australians and indigenous peoples of New Guinea to 98% for indigenous peoples of the Americas. One study has found that non-smokers and those not habituated to coffee or tea have a statistically higher percentage of tasting PTC than the general population. PTC does not occur in food, but related chemicals do, and food choice is related to a person's ability to taste PTC.

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