Perphenazine

Perphenazine
Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a682165
Pregnancy; category	AU: C;
Routes of; administration	Oral and IM
Drug class	Typical antipsychotic
ATC code	N05AB03 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	40%
Metabolism	hepatic
Elimination half-life	8-12 (up to 20) hours
Identifiers
	IUPAC name 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl) propyl]piperazin-1-yl]ethanol;
CAS Number	58-39-9 ;
PubChem CID	4748;
IUPHAR/BPS	209;
DrugBank	DB00850 ;
ChemSpider	4586 ;
UNII	FTA7XXY4EZ;
KEGG	D00503 ;
ChEBI	CHEBI:8028 ;
ChEMBL	ChEMBL567 ;
CompTox Dashboard (EPA)	DTXSID1023441 ;
ECHA InfoCard	100.000.346
Chemical and physical data
Formula	C21H26ClN3OS
Molar mass	403.97 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(CCO)CC4;
	InChI InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2 ; Key:RGCVKNLCSQQDEP-UHFFFAOYSA-N ;
	(verify)

Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been in clinical use for decades.

Perphenazine is roughly ten times as potent as chlorpromazine at the dopamine-2 (D2) receptor; thus perphenazine is considered a medium-potency antipsychotic.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.