Periostin

POSTN
Identifiers
Aliases	POSTN, OSF-2, OSF2, PDLPN, periostin
External IDs	OMIM: 608777 MGI: 1926321 HomoloGene: 4730 GeneCards: POSTN
Gene location (Human)
Chr.	Chromosome 13 (human)
End	37,598,844 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	54,298,458 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; visceral pleura; ; pylorus; ; lactiferous duct; ; parietal pleura; ; cardia; ; left coronary artery; ; smooth muscle tissue; ; rectum; ; ascending aorta;
	Top expressed in
	atrioventricular valve; ; body of femur; ; dermis; ; belly cord; ; external carotid artery; ; internal carotid artery; ; conjunctival fornix; ; calvaria; ; abdominal wall; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; heparin binding; protein binding; extracellular matrix structural constituent; cell adhesion molecule binding;
Cellular component	extracellular region; cytoplasm; trans-Golgi network; Golgi apparatus; extracellular matrix; neuromuscular junction; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of substrate adhesion-dependent cell spreading; regulation of Notch signaling pathway; response to hypoxia; response to mechanical stimulus; neuron projection extension; wound healing; regulation of systemic arterial blood pressure; skeletal system development; response to estradiol; cellular response to fibroblast growth factor stimulus; bone regeneration; tissue development; positive regulation of smooth muscle cell migration; cellular response to transforming growth factor beta stimulus; negative regulation of cell-matrix adhesion; response to muscle activity; cell adhesion; cellular response to tumor necrosis factor; cellular response to vitamin K; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	10631
	50706
	ENSG00000133110
	ENSMUSG00000027750
	Q15063
	Q62009
NM_001135934; NM_001135935; NM_001135936; NM_001286665; NM_001286666;
	NM_001286667; NM_006475; NM_001330517
NM_001198765; NM_001198766; NM_015784; NM_001313898; NM_001313899;
	NM_001368678
NP_001129406; NP_001129407; NP_001129408; NP_001273594; NP_001273595;
	NP_001273596; NP_001317446; NP_006466; NP_006466.2
NP_001185694; NP_001185695; NP_001300827; NP_001300828; NP_056599;
	NP_001355607
	Wikidata
View/Edit Human	View/Edit Mouse

Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a protein that in humans is encoded by the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.

Periostin is a gla domain vitamin K dependent factor.

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