Perindopril

Perindopril
Clinical data
Trade names	Coversyl, Coversum, Aceon
AHFS/Drugs.com	Monograph
Routes of; administration	By mouth
ATC code	C09AA04 (WHO) ; C09BA04 (WHO) (with diuretics); C09BB04 (WHO) (with amlodipine);
Legal status
Legal status	CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	24%
Protein binding	20%
Metabolism	Kidney
Elimination half-life	1–17 hours for perindoprilat (active metabolite)
Identifiers
	IUPAC name (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid;
CAS Number	82834-16-0 ;
PubChem CID	107807;
IUPHAR/BPS	6367;
DrugBank	DB00790 ;
ChemSpider	96956 ;
UNII	Y5GMK36KGY;
KEGG	D03753 ;
ChEBI	CHEBI:8024 ;
ChEMBL	ChEMBL1581 ;
CompTox Dashboard (EPA)	DTXSID6023440 ;
ECHA InfoCard	100.120.843
Chemical and physical data
Formula	C19H32N2O5
Molar mass	368.474 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@H]12)C)CCC;
	InChI InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1 ; Key:IPVQLZZIHOAWMC-QXKUPLGCSA-N ;
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Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease.

As a long-acting ACE inhibitor, it works by relaxing blood vessels and decreasing blood volume. As a prodrug, perindopril is hydrolyzed in the liver to its active metabolite, perindoprilat. It was patented in 1980 and approved for medical use in 1988.

Perindopril is taken in the form of perindopril arginine (with arginine, trade names include Coversyl, Coversum) or perindopril erbumine (with erbumine (tert-Butylamine), trade name Aceon). Both forms are therapeutically equivalent and interchangeable, but the dose prescribed to achieve the same effect differs between the two forms. It is also often combined with another medication, sometimes in the same tablet (see § Combination therapy below).

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