Pemetrexed

Pemetrexed
Clinical data
Trade names	Alimta, Pemfexy, Ciambra, others
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN; US DailyMed: Pemetrexed; US FDA: Pemetrexed;
Pregnancy; category	AU: D;
Routes of; administration	Intravenous
ATC code	L01BA04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	NA
Protein binding	81%
Metabolism	Negligible
Elimination half-life	3.5 hours
Excretion	Kidney
Identifiers
	IUPAC name (2S)-2-{[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino}pentanedioic acid;
CAS Number	137281-23-3 ;
PubChem CID	135410875;
DrugBank	DB00642 ;
ChemSpider	393879 ;
UNII	04Q9AIZ7NO;
KEGG	D07472 ; as salt: D06503 ;
ChEMBL	ChEMBL225072 ;
CompTox Dashboard (EPA)	DTXSID2048329 ;
ECHA InfoCard	100.205.735
Chemical and physical data
Formula	C20H21N5O6
Molar mass	427.417 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Nc3nc2[nH]cc(CCc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)c2c(=O)[nH]3;
	InChI InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1 ; Key:WBXPDJSOTKVWSJ-ZDUSSCGKSA-N ;
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Pemetrexed, sold under the brand name Alimta among others, is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer (NSCLC)..

It is available as a generic medication.

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