Pazopanib

Pazopanib
Clinical data
Pronunciation	/pæˈzoʊpənɪb/ paz-OH-pə-nib
Trade names	Votrient
AHFS/Drugs.com	Monograph
MedlinePlus	a610013
License data	EU EMA: by INN; US DailyMed: Pazopanib; US FDA: Pazopanib;
Pregnancy; category	AU: D;
Routes of; administration	By mouth (tablets)
ATC code	L01EX03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	21% (14–39%)
Protein binding	>99.5%
Metabolism	Liver: CYP3A4 (major), 1A2 and 2C8 (minor)
Elimination half-life	30.9±4 hours
Excretion	Faeces (primary), urine (<4%)
Identifiers
	IUPAC name 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide;
CAS Number	444731-52-6 ; as HCl: 635702-64-6 ;
PubChem CID	11525740;
IUPHAR/BPS	5698;
DrugBank	DB06589 ;
ChemSpider	9700526 ;
UNII	7RN5DR86CK; as HCl: 33Y9ANM545 ;
KEGG	D05380 ;
ChEBI	CHEBI:71219 ;
ChEMBL	ChEMBL477772 ;
CompTox Dashboard (EPA)	DTXSID8048733 ;
Chemical and physical data
Formula	C21H23N7O2S
Molar mass	437.52 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(N)c1c(ccc(c1)Nc2nccc(n2)N(c4ccc3c(nn(c3C)C)c4)C)C;
	InChI InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H ; Key:MQHIQUBXFFAOMK-UHFFFAOYSA-N ;
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Pazopanib, sold under the brand name Votrient, is an anti-cancer medication marketed worldwide by Novartis. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. It has been approved for renal cell carcinoma and soft tissue sarcoma by numerous regulatory administrations worldwide.

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