PAX6

PAX6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CUE, 6PAX
Identifiers
Aliases	PAX6, AN, AN2, D11S812E, FVH1, MGDA, WAGR, paired box 6, ASGD5
External IDs	OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6
Gene location (Human)
Chr.	Chromosome 11 (human)
End	31,818,062 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	105,527,709 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; ganglionic eminence; ; cerebellar vermis; ; pons; ; external globus pallidus; ; Region I of hippocampus proper; ; middle frontal gyrus; ; retinal pigment epithelium; ; entorhinal cortex; ; putamen;
	Top expressed in
	corneal stroma; ; lens; ; corneal epithelium; ; iris; ; islet of Langerhans; ; ciliary body; ; conjunctival fornix; ; lacrimal gland; ; cerebellar cortex; ; optic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA binding; sequence-specific DNA binding; ubiquitin-protein transferase activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; DNA-binding transcription factor activity; transcription factor binding; protein kinase binding; ubiquitin protein ligase binding; histone acetyltransferase binding; co-SMAD binding; R-SMAD binding; HMG box domain binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol; intracellular anatomical structure;
Biological process	eye development; blood vessel development; animal organ morphogenesis; regulation of transcription, DNA-templated; glucose homeostasis; transcription, DNA-templated; central nervous system development; response to wounding; cell differentiation; cornea development in camera-type eye; negative regulation of neurogenesis; visual perception; iris morphogenesis; multicellular organism development; neuron fate commitment; protein ubiquitination; negative regulation of transcription by RNA polymerase II; establishment of mitotic spindle orientation; cell fate determination; neuron migration; negative regulation of protein phosphorylation; positive regulation of neuroblast proliferation; lens development in camera-type eye; regionalization; type B pancreatic cell differentiation; pancreatic A cell development; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; smoothened signaling pathway; axonogenesis; axon guidance; brain development; salivary gland morphogenesis; negative regulation of cell population proliferation; regulation of asymmetric cell division; dorsal/ventral axis specification; anterior/posterior pattern specification; dorsal/ventral pattern formation; regulation of gene expression; positive regulation of gene expression; pallium development; oligodendrocyte cell fate specification; cerebral cortex regionalization; forebrain dorsal/ventral pattern formation; commitment of neuronal cell to specific neuron type in forebrain; forebrain-midbrain boundary formation; telencephalon regionalization; pituitary gland development; habenula development; signal transduction involved in regulation of gene expression; keratinocyte differentiation; regulation of cell migration; positive regulation of epithelial cell differentiation; forebrain development; lacrimal gland development; protein localization to organelle; eye photoreceptor cell development; camera-type eye development; cell fate commitment; negative regulation of neuron differentiation; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of timing of cell differentiation; embryonic camera-type eye morphogenesis; astrocyte differentiation; negative regulation of epithelial cell proliferation; regulation of neurogenesis; retina development in camera-type eye; cellular response to leukemia inhibitory factor; negative regulation of neural precursor cell proliferation; positive regulation of core promoter binding;
	Sources:Amigo / QuickGO
Orthologs
	5080
	18508
	ENSG00000007372
	ENSMUSG00000027168
	P26367
	P63015
NM_000280; NM_001127612; NM_001258462; NM_001258463; NM_001258464;
	NM_001258465; NM_001310158; NM_001310159; NM_001310160; NM_001310161; NM_001604
NM_001244198; NM_001244200; NM_001244201; NM_001244202; NM_013627;
	NM_001310144; NM_001310145; NM_001310146
NP_000271; NP_001121084; NP_001245391; NP_001245392; NP_001245393;
	NP_001245394; NP_001297087; NP_001297088; NP_001297089; NP_001297090; NP_001595; NP_001355816; NP_001355817; NP_001355818; NP_001355819; NP_001355820; NP_001355821; NP_001355822; NP_001355823; NP_001355828; NP_001355829; NP_001355830; NP_001355831; NP_001355832; NP_001355833; NP_001355834; NP_001355835; NP_001355836; NP_001355837; NP_001355838; NP_001355839; NP_001355840; NP_001355841; NP_001355842; NP_001355843; NP_001355844; NP_001355845; NP_001355846; NP_001355847; NP_001355848; NP_001355849; NP_001355850; NP_001355851; NP_001355852; NP_001355853; NP_001355854; NP_001355855; NP_001355856; NP_001355857; NP_001355858; NP_001355859
NP_001231127; NP_001231129; NP_001231130; NP_001231131; NP_001297073;
	NP_001297074; NP_001297075; NP_038655
	Wikidata
View/Edit Human	View/Edit Mouse

Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.