PTPRJ

PTPRJ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CFV, 2DLE, 2NZ6
Identifiers
Aliases	PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J, protein tyrosine phosphatase receptor type J, R-PTP-J, HPTP eta
External IDs	OMIM: 600925 MGI: 104574 HomoloGene: 2130 GeneCards: PTPRJ
Gene location (Human)
Chr.	Chromosome 11 (human)
End	48,170,839 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,410,991 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; parotid gland; ; renal medulla; ; pylorus; ; bone marrow cells; ; palpebral conjunctiva; ; jejunal mucosa; ; internal globus pallidus; ; cardia;
	Top expressed in
	olfactory tubercle; ; dentate gyrus; ; primary motor cortex; ; lateral geniculate nucleus; ; piriform cortex; ; ascending aorta; ; blood; ; cingulate gyrus; ; lacrimal gland; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; phosphoprotein phosphatase activity; gamma-catenin binding; phosphatase activity; delta-catenin binding; mitogen-activated protein kinase binding; platelet-derived growth factor receptor binding; protein binding; hydrolase activity; protein kinase binding; protein tyrosine phosphatase activity;
Cellular component	integral component of membrane; cell projection; membrane; cell-cell junction; plasma membrane; integral component of plasma membrane; ruffle membrane; cell surface; cell junction; immunological synapse; extracellular exosome; specific granule membrane;
Biological process	negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling; positive regulation of protein kinase B signaling; negative regulation of epidermal growth factor receptor signaling pathway; protein dephosphorylation; contact inhibition; negative regulation of T cell receptor signaling pathway; regulation of cell adhesion; negative regulation of cell migration; negative regulation of MAP kinase activity; negative regulation of cell growth; positive regulation of focal adhesion assembly; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; peptidyl-tyrosine dephosphorylation; T cell receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of vascular permeability; positive regulation of cell adhesion; dephosphorylation; neutrophil degranulation; B cell differentiation; positive regulation of tumor necrosis factor production; calcium-mediated signaling using intracellular calcium source; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5795
	19271
	ENSG00000149177
	ENSMUSG00000025314
	Q12913
	Q64455
	NM_001098503; NM_002843
	NM_001135657; NM_008982
	NP_001091973; NP_002834
	NP_001129129; NP_033008
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.

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