PTPN6

PTPN6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ
Identifiers
Aliases	PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, protein tyrosine phosphatase, non-receptor type 6, protein tyrosine phosphatase non-receptor type 6
External IDs	OMIM: 176883 MGI: 96055 HomoloGene: 56589 GeneCards: PTPN6
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,961,316 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,715,677 bp
RNA expression pattern
	Top expressed in
	spleen; ; monocyte; ; blood; ; bone marrow cells; ; appendix; ; lymph node; ; right lung; ; upper lobe of left lung; ; spongy bone; ; right adrenal gland;
	Top expressed in
	spleen; ; thymus; ; blood; ; right lung lobe; ; lip; ; subcutaneous adipose tissue; ; yolk sac; ; submandibular gland; ; duodenum; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; SH3 domain binding; phosphatase activity; phosphotyrosine residue binding; SH2 domain binding; protein binding; transmembrane receptor protein tyrosine phosphatase activity; hydrolase activity; protein kinase binding; cell adhesion molecule binding; protein tyrosine phosphatase activity; phosphorylation-dependent protein binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; alpha-beta T cell receptor complex; nucleolus; extracellular exosome; nucleus; extracellular region; specific granule lumen; tertiary granule lumen; nucleoplasm; protein-containing complex;
Biological process	B cell receptor signaling pathway; megakaryocyte development; G protein-coupled receptor signaling pathway; cell differentiation; intracellular signal transduction; regulation of release of sequestered calcium ion into cytosol; abortive mitotic cell cycle; T cell costimulation; protein dephosphorylation; platelet formation; negative regulation of T cell receptor signaling pathway; platelet activation; negative regulation of humoral immune response mediated by circulating immunoglobulin; regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; regulation of type I interferon-mediated signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of MAP kinase activity; hematopoietic progenitor cell differentiation; positive regulation of cell population proliferation; negative regulation of MAPK cascade; regulation of ERK1 and ERK2 cascade; negative regulation of B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of cell adhesion mediated by integrin; cell population proliferation; platelet aggregation; regulation of B cell differentiation; leukocyte migration; natural killer cell mediated cytotoxicity; negative regulation of cell population proliferation; dephosphorylation; apoptotic process; neutrophil degranulation; peptidyl-tyrosine dephosphorylation; cytokine-mediated signaling pathway; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5777
	15170
	ENSG00000111679
	ENSMUSG00000004266
	P29350
	P29351
	NM_002831; NM_080548; NM_080549
	NM_001077705; NM_013545
	NP_002822; NP_536858; NP_536859
	NP_001071173; NP_038573
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.

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