PRDX3

PRDX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5JCG
Identifiers
Aliases	PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III, peroxiredoxin 3, SCAR32, PPPCD
External IDs	OMIM: 604769 MGI: 88034 HomoloGene: 4944 GeneCards: PRDX3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,178,812 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	60,862,994 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; right ventricle; ; biceps brachii; ; oocyte; ; islet of Langerhans; ; gastrocnemius muscle; ; secondary oocyte; ; vastus lateralis muscle; ; right lobe of liver; ; thoracic diaphragm;
	Top expressed in
	adrenal gland; ; digastric muscle; ; right ventricle; ; temporal muscle; ; soleus muscle; ; sternocleidomastoid muscle; ; myocardium of ventricle; ; brown adipose tissue; ; triceps brachii muscle; ; interventricular septum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peroxidase activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase binding; protein C-terminus binding; protein binding; antioxidant activity; alkyl hydroperoxide reductase activity; peroxiredoxin activity; oxidoreductase activity; protein kinase binding; thioredoxin peroxidase activity; identical protein binding;
Cellular component	cytosol; myelin sheath; mitochondrial matrix; mitochondrion; IkappaB kinase complex; cytoplasm; endosome; early endosome; protein-containing complex;
Biological process	myeloid cell differentiation; peptidyl-cysteine oxidation; mitochondrion organization; negative regulation of apoptotic process; response to oxidative stress; regulation of mitochondrial membrane potential; cellular response to reactive oxygen species; response to lipopolysaccharide; maternal placenta development; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell population proliferation; hydrogen peroxide catabolic process; response to hydrogen peroxide; negative regulation of kinase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular oxidant detoxification; cell redox homeostasis; apoptotic process; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	10935
	11757
	ENSG00000165672
	ENSMUSG00000024997
	P30048
	P20108
	NM_001302272; NM_006793; NM_014098
	NM_007452
	NP_001289201; NP_006784
	NP_031478
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin-dependent peroxide reductase, mitochondrial is an enzyme that in humans is encoded by the PRDX3 gene. It is a member of the peroxiredoxin family of antioxidant enzymes.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.