Peroxiredoxin 2

PRDX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QMV
Identifiers
Aliases	PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
External IDs	OMIM: 600538 MGI: 109486 HomoloGene: 21182 GeneCards: PRDX2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,801,800 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,701,463 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; external globus pallidus; ; pons; ; right ventricle; ; left adrenal gland; ; superior vestibular nucleus; ; embryo; ; prefrontal cortex; ; left ventricle; ; ganglionic eminence;
	Top expressed in
	superior frontal gyrus; ; lip; ; yolk sac; ; motor neuron; ; maxillary prominence; ; aortic valve; ; secondary oocyte; ; neural tube; ; ascending aorta; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; antioxidant activity; peroxiredoxin activity; peroxidase activity; protein binding; thioredoxin peroxidase activity;
Cellular component	cytoplasm; extracellular exosome; cytosol;
Biological process	regulation of apoptotic process; negative regulation of apoptotic process; hydrogen peroxide catabolic process; cell redox homeostasis; response to oxidative stress; cellular response to oxidative stress; removal of superoxide radicals; respiratory burst involved in inflammatory response; regulation of hydrogen peroxide metabolic process; positive regulation of blood coagulation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of NF-kappaB transcription factor activity; response to lipopolysaccharide; T cell proliferation; hydrogen peroxide metabolic process; negative regulation of T cell differentiation; thymus development; homeostasis of number of cells; negative regulation of reactive oxygen species metabolic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; leukocyte activation;
	Sources:Amigo / QuickGO
Orthologs
	7001
	21672
	ENSG00000167815
	ENSMUSG00000005161
	P32119
	Q61171
	NM_181738; NM_005809; NM_181737
	NM_011563; NM_001317385
	NP_005800
	NP_001304314; NP_035693
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.

PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene.

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