PR toxin

Penicillin Roquefort Toxin (PR toxin) is a mycotoxin produced by the fungi Penicillium roqueforti. In 1973, PR toxin was first partially characterized by isolating moldy corn on which the fungi had grown. Although its lethal dose was determined shortly after the isolation of the chemical, details of its toxic effects were not fully clarified until 1982 in a study with mice, rats, anesthetized cats and preparations of isolated rat auricles.

PR toxin
Names
IUPAC name
(11S)-8,12-Dioxo-1β,2β:7,11-diepoxy-7α-eremophil-9-en-3β-yl acetate
Systematic IUPAC name
(1aR,2R,2′R,3R,3′S,3aR,7bS)-3′-Formyl-3,3′,3a-trimethyl-6-oxo-1a,2,3a,4,6,7b-hexahydro-3H-spiro[naphtho[1,2-b]oxirene-5,2′-oxiran]-2-yl acetate
Identifiers
3D model (JSmol)
3DMet
ChEBI
ChEMBL
ChemSpider
KEGG
UNII
  • InChI=1S/C17H20O6/c1-8-12(21-9(2)19)14-13(22-14)10-5-11(20)17(6-15(8,10)3)16(4,7-18)23-17/h5,7-8,12-14H,6H2,1-4H3/t8-,12+,13-,14+,15+,16+,17-/m0/s1
    Key: GSPFUBNBRPVALJ-VIEAGMIOSA-N
  • C[C@H]1[C@H]([C@@H]2[C@@H](O2)C3=CC(=O)[C@@]4(C[C@]13C)[C@@](O4)(C)C=O)OC(=O)C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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