PON1

PON1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V04
Identifiers
Aliases	PON1, ESA, MVCD5, PON, paraoxonase 1
External IDs	OMIM: 168820 MGI: 103295 HomoloGene: 68058 GeneCards: PON1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	95,324,532 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	5,193,946 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; left adrenal gland; ; secondary oocyte; ; right adrenal gland; ; gallbladder; ; thymus; ; islet of Langerhans; ; pituitary gland; ; anterior pituitary; ; amygdala;
	Top expressed in
	retinal pigment epithelium; ; olfactory epithelium; ; left lobe of liver; ; right lung lobe; ; left lung; ; left lung lobe; ; carotid body; ; gallbladder; ; trachea; ; digastric muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; metal ion binding; aryldialkylphosphatase activity; arylesterase activity; hydrolase activity; phospholipid binding; acyl-L-homoserine-lactone lactonohydrolase activity;
Cellular component	blood microparticle; intracellular membrane-bounded organelle; spherical high-density lipoprotein particle; high-density lipoprotein particle; extracellular exosome; extracellular region; extracellular space;
Biological process	response to fatty acid; positive regulation of transporter activity; negative regulation of plasma lipoprotein oxidation; lipid metabolism; carboxylic acid catabolic process; cholesterol metabolic process; positive regulation of binding; response to nutrient levels; response to fluoride; positive regulation of cholesterol efflux; response to external stimulus; organophosphate catabolic process; aromatic compound catabolic process; phosphatidylcholine metabolic process; response to toxic substance; dephosphorylation; lipoxygenase pathway;
	Sources:Amigo / QuickGO
Orthologs
	5444
	18979
	ENSG00000005421
	ENSMUSG00000002588
	P27169
	P52430
	NM_000446
	NM_011134
	NP_000437
	NP_035264
	Wikidata
View/Edit Human	View/Edit Mouse

Serum paraoxonase and arylesterase 1 (PON1) also known as A esterase , homocysteine thiolactonase or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. PON1 is the first discovered member of a multigene family also containing PON2 and PON3, the genes for which are located adjacent to each other on chromosome 7. It has recently been shown that PON1 on HDL (different from soluble PON1) is responsible for significant atheroprotection rendered by the HDL.

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