PLSCR3

PLSCR3
Identifiers
Aliases	PLSCR3, phospholipid scramblase 3
External IDs	OMIM: 607611 MGI: 1917560 HomoloGene: 23219 GeneCards: PLSCR3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,394,843 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,742,884 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; left coronary artery; ; ascending aorta; ; tibial nerve; ; myometrium; ; left uterine tube; ; canal of the cervix; ; spleen; ; vagina;
	Top expressed in
	lip; ; external carotid artery; ; internal carotid artery; ; molar; ; calvaria; ; atrium; ; lung; ; trigeminal ganglion; ; condyle; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; phospholipid scramblase activity; calcium ion binding; protein binding; calcium-dependent protein binding;
Cellular component	integral component of membrane; plasma membrane; mitochondrial membranes; membrane; mitochondrion;
Biological process	cholesterol homeostasis; cellular response to lipopolysaccharide; plasma membrane phospholipid scrambling; glucose homeostasis; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	57048
	70310
	ENSG00000187838; ENSG00000284009
	ENSMUSG00000019461
	Q9NRY6
	Q9JIZ9
	NM_020360; NM_001201576
	NM_001168497; NM_023564
NP_001188505; NP_065093; NP_001356336; NP_001356349; NP_001356350;
	NP_001356351
	NP_001161969; NP_076053
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipid scramblase 3 is an enzyme that in humans is encoded by the PLSCR3 gene (abbreviated to PLS3 in this section). Like the other phospholipid scramblase family members (PLS1, PLS2, PLS4), PLS3 is a type II plasma membrane protein that is rich in proline and integral in apoptosis, or programmed cell death. The regulation of apoptosis is critical for both cell development and tissue homeostasis

Although phospholipid scramblase is thought to exist in all eukaryotic cells, PLS3 is a protein that is novel to the mitochondria. This is very important because mitochondria are central in the apoptotic cell pathway. This newly found member of the scramblase family is "responsible for phospholipid translocation between two lipid compartments," the inner mitochondrial membrane and the outer membrane. Further experimental evidence suggests that the mechanism and effectors of PLS3's enzymatic activity are rather nuanced.

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