PLAT domain
In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.
| PLAT/LH2 domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the lipase-procolipase complex. | |||||||||
| Identifiers | |||||||||
| Symbol | PLAT | ||||||||
| Pfam | PF01477 | ||||||||
| InterPro | IPR001024 | ||||||||
| SMART | SM00308 | ||||||||
| PROSITE | PDOC50095 | ||||||||
| SCOP2 | 1lpa / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 221 | ||||||||
| OPM protein | 3swz | ||||||||
| CDD | cd00113 | ||||||||
| |||||||||
This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.
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