Phosphoinositide 3-kinase
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
| Phosphatidylinositol-4,5-bisphosphate 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
PIK-93 inhibitor (yellow) bound to the PI3K 110 gamma subunit . | |||||||||
| Identifiers | |||||||||
| Symbol | PI3K | ||||||||
| Pfam | PF00454 | ||||||||
| InterPro | IPR000403 | ||||||||
| SMART | SM00146 | ||||||||
| PROSITE | PDOC00710 | ||||||||
| SCOP2 | 3gmm / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 265 | ||||||||
| OPM protein | 3ml9 | ||||||||
| |||||||||
| Phosphoinositide 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.137 | ||||||||
| CAS no. | 115926-52-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
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