PHEX

PHEX
Identifiers
Aliases	PHEX, HPDR, HPDR1, HYP, HYP1, LXHR, PEX, XLH, phosphate regulating endopeptidase homolog, X-linked, phosphate regulating endopeptidase homolog X-linked
External IDs	OMIM: 300550 MGI: 107489 HomoloGene: 37310 GeneCards: PHEX
Gene location (Human)
Chr.	X chromosome (human)
End	22,494,713 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	156,198,308 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibia; ; right lung; ; jejunal mucosa; ; upper lobe of left lung; ; smooth muscle tissue; ; myometrium; ; duodenum; ; internal globus pallidus; ; gallbladder;
	Top expressed in
	molar; ; body of femur; ; fossa; ; calvaria; ; cumulus cell; ; left lung lobe; ; cerebellar vermis; ; cochlea; ; condyle; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; peptidase activity; metalloendopeptidase activity; aminopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	perinuclear region of cytoplasm; integral component of membrane; plasma membrane; Golgi apparatus; integral component of plasma membrane; endoplasmic reticulum; membrane;
Biological process	organophosphate metabolic process; skeletal system development; cell-cell signaling; bone mineralization; biomineral tissue development; proteolysis; lung development; response to vitamin D; bone development; response to growth hormone; cellular response to vitamin D; cellular response to parathyroid hormone stimulus; response to sodium phosphate; response to insulin-like growth factor stimulus; odontogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5251
	18675
	ENSG00000102174
	ENSMUSG00000057457
	P78562
	P70669
	NM_000444; NM_001282754
	NM_011077
	NP_000435; NP_001269683
	NP_035207
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphate-regulating endopeptidase homolog X-linked also known as phosphate-regulating gene with homologies to endopeptidases on the X chromosome or metalloendopeptidase homolog PEX is an enzyme that in humans is encoded by the PHEX gene. This gene contains 18 exons and is located on the X chromosome.

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