PGRMC1

PGRMC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4X8Y
Identifiers
Aliases	PGRMC1, HPR6.6, MPR, progesterone receptor membrane component 1, Dap1, IZA
External IDs	OMIM: 300435 MGI: 1858305 HomoloGene: 48457 GeneCards: PGRMC1
Gene location (Human)
Chr.	X chromosome (human)
End	119,244,466 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	35,869,732 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; caput epididymis; ; corpus epididymis; ; bronchial epithelial cell; ; pons; ; endometrium; ; middle temporal gyrus; ; kidney tubule; ; jejunal mucosa; ; germinal epithelium;
	Top expressed in
	olfactory epithelium; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; ventromedial nucleus; ; suprachiasmatic nucleus; ; left lobe of liver; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; median eminence; ; mammillary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	steroid binding; protein binding; heme binding; lipid binding; amyloid-beta binding;
Cellular component	organelle membrane; integral component of membrane; extracellular exosome; endoplasmic reticulum membrane; endomembrane system; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; plasma membrane; specific granule membrane; integral component of plasma membrane; smooth endoplasmic reticulum membrane; neuron projection; neuronal cell body; cell body; synapse;
Biological process	neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	10857
	53328
	ENSG00000101856
	ENSMUSG00000006373
	O00264; Q6IB11
	O55022
	NM_006667; NM_001282621
	NM_016783
	NP_001269550; NP_006658; NP_006658.1
	NP_058063
	Wikidata
View/Edit Human	View/Edit Mouse

Progesterone receptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans, the PGRMC1 protein is encoded by the PGRMC1 gene.

The sole biochemical function of PGRMC1 is heme-binding. PGRMC1 shares key structural motifs with cytochrome b₅. PGRMC1 binds and activates P450 proteins, which are important in drug, hormone and lipid metabolism. PGRMC1 also binds to PAIR-BP1 (plasminogen activator inhibitor RNA-binding protein-1). However, its expression outside of the reproductive tract and in males suggests multiple functions for the protein. These may include binding to Insig (insulin-induced gene), which regulates cholesterol synthesis.

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