PPARGC1A

PPARGC1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XB7, 3B1M, 3CS8, 3D24, 3U9Q, 3V9T, 3V9V, 4QJR, 4QK4
Identifiers
Aliases	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α
External IDs	OMIM: 604517 MGI: 1342774 HomoloGene: 7485 GeneCards: PPARGC1A
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	51,725,068 bp
RNA expression pattern
	n/a
	Top expressed in
	atrioventricular valve; ; retinal pigment epithelium; ; lateral geniculate nucleus; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; substantia nigra; ; ciliary body; ; pontine nuclei; ; barrel cortex; ; globus pallidus;
	More reference expression data
Gene ontology
Molecular function	promoter-specific chromatin binding; transcription factor binding; chromatin binding; protein binding; nuclear receptor binding; nucleic acid binding; DNA binding; sequence-specific DNA binding; transcription coactivator activity; alpha-tubulin binding; transcription coregulator activity; androgen receptor binding; nuclear receptor coactivator activity; RNA binding; chromatin DNA binding; ubiquitin protein ligase binding; signaling receptor binding; estrogen receptor binding; peroxisome proliferator activated receptor binding;
Cellular component	cytoplasm; cytosol; cytosolic ribosome; nucleus; RNA polymerase II, core complex; apical dendrite; neuronal cell body; PML body; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	negative regulation of neuron apoptotic process; response to dietary excess; negative regulation of glycolytic process; response to fructose; cellular response to interleukin-6; rhythmic process; cellular response to resveratrol; response to thyroid hormone; cellular response to fructose stimulus; cellular response to ionomycin; adaptive thermogenesis; response to ischemia; circadian rhythm; fatty acid oxidation; response to metformin; cellular response to caffeine; response to electrical stimulus involved in regulation of muscle adaptation; temperature homeostasis; cellular response to hypoxia; cellular response to glucose stimulus; positive regulation of fatty acid oxidation; cellular response to transforming growth factor beta stimulus; positive regulation of progesterone biosynthetic process; regulation of transcription, DNA-templated; cellular response to follicle-stimulating hormone stimulus; androgen metabolic process; response to reactive oxygen species; positive regulation of mitochondrial DNA metabolic process; digestion; response to leucine; response to norepinephrine; response to epinephrine; transcription, DNA-templated; negative regulation of mitochondrial fission; positive regulation of transcription, DNA-templated; positive regulation of glomerular visceral epithelial cell apoptotic process; response to nutrient levels; RNA splicing; skeletal muscle atrophy; cellular respiration; negative regulation of signaling receptor activity; positive regulation of gluconeogenesis; transcription initiation from RNA polymerase II promoter; cellular response to potassium ion; negative regulation of neuron death; negative regulation of protein phosphorylation; positive regulation of cellular respiration; mRNA processing; protein stabilization; mitochondrion organization; positive regulation of DNA-binding transcription factor activity; response to electrical stimulus; circadian regulation of gene expression; cerebellum development; positive regulation of ATP biosynthetic process; regulation of NMDA receptor activity; galactose metabolic process; positive regulation of muscle tissue development; regulation of circadian rhythm; flavone metabolic process; adipose tissue development; respiratory electron transport chain; positive regulation of cellular metabolic process; response to muscle activity; cellular response to nitrite; positive regulation of smooth muscle cell proliferation; gluconeogenesis; androgen receptor signaling pathway; negative regulation of smooth muscle cell proliferation; response to hypoxia; response to organic cyclic compound; cellular glucose homeostasis; cellular response to tumor necrosis factor; cellular response to estradiol stimulus; human ageing; negative regulation of smooth muscle cell migration; response to activity; positive regulation of histone acetylation; cellular response to fatty acid; autophagy of mitochondrion; cellular response to thyroid hormone stimulus; response to methionine; response to starvation; response to cold; cellular response to oxidative stress; forebrain development; cellular response to lipopolysaccharide; positive regulation of transcription by RNA polymerase II; positive regulation of mitochondrion organization; brown fat cell differentiation; protein-containing complex assembly; energy homeostasis; positive regulation of gene expression; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10891
	19017
	ENSG00000109819
	ENSMUSG00000029167
	Q9UBK2
	O70343
	NM_013261; NM_001330751; NM_001330752; NM_001330753
	NM_008904
NP_001317680; NP_001317681; NP_001317682; NP_037393; NP_001341754;
	NP_001341755; NP_001341756; NP_001341757
NP_032930; NP_001389916; NP_001389917; NP_001389918; NP_001389919;
	NP_001389920
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes.

PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogenesis.

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