PDGFRB

PDGFRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG
Identifiers
Aliases	PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta
External IDs	OMIM: 173410 MGI: 97531 HomoloGene: 1960 GeneCards: PDGFRB
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,155,872 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,218,133 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; canal of the cervix; ; gallbladder; ; Achilles tendon; ; right lung; ; left coronary artery; ; ascending aorta; ; left uterine tube; ; gastric mucosa;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; calvaria; ; left lung lobe; ; vas deferens; ; body of femur; ; dermis; ; ascending aorta; ; aortic valve; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor binding; kinase activity; platelet-derived growth factor-activated receptor activity; transmembrane receptor protein tyrosine kinase activity; signaling receptor binding; ATP binding; protein kinase activity; platelet-derived growth factor binding; platelet activating factor receptor activity; transferase activity; platelet-derived growth factor receptor binding; protein binding; protein tyrosine kinase activity; protein kinase binding; platelet-derived growth factor beta-receptor activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; enzyme binding;
Cellular component	cytoplasm; membrane; focal adhesion; nucleus; apical plasma membrane; lysosome; extracellular exosome; integral component of membrane; plasma membrane; lysosomal lumen; intrinsic component of plasma membrane; cytoplasmic vesicle; cell surface; Golgi apparatus; integral component of plasma membrane; intracellular membrane-bounded organelle; receptor complex;
Biological process	positive regulation of MAP kinase activity; positive regulation of phospholipase C activity; cell migration involved in vasculogenesis; cardiac myofibril assembly; positive regulation of smooth muscle cell migration; protein phosphorylation; response to lipid; positive regulation of phosphoprotein phosphatase activity; positive regulation of reactive oxygen species metabolic process; metanephric glomerular mesangial cell proliferation involved in metanephros development; positive regulation of ERK1 and ERK2 cascade; cell chemotaxis; inner ear development; metanephric S-shaped body morphogenesis; positive regulation of mitotic nuclear division; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of collagen biosynthetic process; phosphatidylinositol metabolic process; transmembrane receptor protein tyrosine kinase signaling pathway; cell migration involved in coronary angiogenesis; metanephric comma-shaped body morphogenesis; positive regulation of chemotaxis; positive regulation of DNA biosynthetic process; protein autophosphorylation; platelet-derived growth factor receptor signaling pathway; response to toxic substance; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; regulation of actin cytoskeleton organization; response to retinoic acid; phosphorylation; response to hyperoxia; retina vasculature development in camera-type eye; metanephric glomerulus morphogenesis; metanephric mesenchymal cell migration; wound healing; cellular response to platelet-derived growth factor stimulus; negative regulation of apoptotic process; response to fluid shear stress; response to estrogen; chemotaxis; metanephric mesenchyme development; response to hydrogen peroxide; positive regulation of smooth muscle cell proliferation; response to estradiol; intracellular signal transduction; response to organic cyclic compound; smooth muscle cell chemotaxis; positive regulation of cell migration; aorta morphogenesis; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; metanephric glomerular capillary formation; multicellular organism development; positive regulation of calcium ion import; glycosaminoglycan biosynthetic process; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; cell migration; signal transduction; positive regulation of Rho protein signal transduction; G protein-coupled receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; positive regulation of hepatic stellate cell activation; positive regulation of fibroblast proliferation; positive regulation of apoptotic process; human ageing; male gonad development; lung growth; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; phosphatidylinositol-mediated signaling; positive regulation of protein kinase B signaling; hematopoietic progenitor cell differentiation; positive regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	5159
	18596
	ENSG00000113721
	ENSMUSG00000024620
	P09619
	P05622
	NM_002609; NM_001355016; NM_001355017
	NM_001146268; NM_008809
	NP_002600; NP_001341945; NP_001341946
	NP_001139740; NP_032835
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.