PDE4A

PDE4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QYK, 3I8V, 3TVX
Identifiers
Aliases	PDE4A, DPDE2, PDE4, PDE46, phosphodiesterase 4A
External IDs	OMIM: 600126 MGI: 99558 HomoloGene: 4520 GeneCards: PDE4A
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,469,630 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,124,544 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; cingulate gyrus; ; cerebellar vermis; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; orbitofrontal cortex;
	Top expressed in
	superior frontal gyrus; ; spermatid; ; seminiferous tubule; ; cerebellar cortex; ; right ventricle; ; olfactory epithelium; ; skeletal muscle tissue; ; primary motor cortex; ; knee joint; ; parotid gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; cAMP binding; protein binding; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; 3',5'-cyclic-AMP phosphodiesterase activity;
Cellular component	cytoplasm; ruffle membrane; perinuclear region of cytoplasm; cytosol; cell projection; membrane; nucleoplasm; plasma membrane;
Biological process	sensory perception of smell; regulation of cAMP-mediated signaling; cAMP catabolic process; regulation of protein kinase A signaling; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5141
	18577
	ENSG00000065989
	ENSMUSG00000032177
	P27815
	O89084
	NM_001111307; NM_001111308; NM_001111309; NM_001243121; NM_006202
	NM_019798; NM_183408; NM_001310750
	NP_001104777; NP_001104778; NP_001104779; NP_001230050; NP_006193
	NP_001297679; NP_062772; NP_899668
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.

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