PCSK6

PCSK6
Identifiers
Aliases	PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6
External IDs	OMIM: 167405 MGI: 102897 HomoloGene: 20569 GeneCards: PCSK6
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,525,202 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,700,134 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; middle frontal gyrus; ; corpus callosum; ; spleen; ; inferior ganglion of vagus nerve; ; inferior olivary nucleus; ; synovial joint; ; subthalamic nucleus; ; pons;
	Top expressed in
	ankle; ; calvaria; ; stria vascularis; ; lip; ; esophagus; ; left lobe of liver; ; membranous bone; ; body of femur; ; cerebellar vermis; ; maxilla;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; nerve growth factor binding; peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity; endopeptidase activity; protein binding;
Cellular component	membrane; extracellular matrix; cell surface; endoplasmic reticulum; Golgi lumen; endomembrane system; extracellular region; extracellular space; plasma membrane; collagen-containing extracellular matrix;
Biological process	glycoprotein metabolic process; secretion by cell; protein processing; proteolysis; regulation of BMP signaling pathway; determination of left/right symmetry; peptide hormone processing; zygotic determination of anterior/posterior axis, embryo; nerve growth factor production; cornification; regulation of lipoprotein lipase activity; nerve growth factor processing;
	Sources:Amigo / QuickGO
Orthologs
	5046
	18553
	ENSG00000140479
	ENSMUSG00000030513
	P29122
	n/a
NM_138325; NM_001291309; NM_002570; NM_138319; NM_138320;
	NM_138321; NM_138322; NM_138323; NM_138324
	NM_001291184; NM_011048
NP_001278238; NP_002561; NP_612192; NP_612195; NP_612196;
	NP_612197; NP_612198
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. Pcsk6 is a calcium-dependent serine endoprotease that catalyzes the post-translational modification of precursor proteins from its ‘latent’ form to the cleaved ‘active’ form. Active Pcsk6 has been reported to process substrates such as transforming growth factor β, pro-albumin, von Willebrand factor, and corin. Clinically, Pcsk6 is suggested to play a role in left/right asymmetry, structural asymmetry of the brain, handedness, tumor progression, hemostasis, and cardiovascular diseases.

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