PCSK4

PCSK4
Identifiers
Aliases	PCSK4, PC4, SPC5, proprotein convertase subtilisin/kexin type 4
External IDs	OMIM: 600487 MGI: 97514 HomoloGene: 22495 GeneCards: PCSK4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,490,752 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,329,498 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; right lobe of liver; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; hypothalamus; ; cingulate gyrus; ; stromal cell of endometrium; ; nucleus accumbens; ; Brodmann area 9;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; outer nuclear layer; ; proximal tubule; ; liver; ; islet of Langerhans; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; protein binding; serine-type endopeptidase activity;
Cellular component	integral component of membrane; membrane; acrosomal membrane; cytoplasmic vesicle; acrosomal vesicle; trans-Golgi network; integral component of Golgi membrane;
Biological process	proteolysis; binding of sperm to zona pellucida; sperm capacitation; acrosome reaction; fertilization; reproductive process; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
	54760
	18551
	ENSG00000115257
	ENSMUSG00000020131
	Q6UW60
	P29121
	NM_017573; NM_001395257
	NM_008793
	NP_060043
	NP_032819
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.

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