PCNT

PCNT
Identifiers
Aliases	PCNT, KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin
External IDs	OMIM: 605925 HomoloGene: 86942 GeneCards: PCNT
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,445,769 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of tongue; ; thoracic diaphragm; ; triceps brachii muscle; ; biceps brachii; ; middle temporal gyrus; ; sural nerve; ; pituitary gland; ; anterior pituitary; ; superior surface of tongue;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calmodulin binding; molecular adaptor activity;
Cellular component	centriole; centrosome; centriolar satellite; microtubule; membrane; cytoskeleton; cytoplasm; microtubule organizing center; cytosol;
Biological process	positive regulation of intracellular protein transport; mitotic spindle organization; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; cilium assembly; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5116
	n/a
	ENSG00000160299
	n/a
	O95613
	n/a
	NM_006031; NM_001315529
	n/a
	NP_001302458; NP_006022
	n/a
	Wikidata
View/Edit Human

Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome.

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