Proliferating cell nuclear antigen

PCNA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D2G, 1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3P87, 3TBL, 3VKX, 3WGW, 4RJF, 3JA9, 4ZTD, 5IY4, 5E0U, 5E0T, 5E0V
Identifiers
Aliases	PCNA, ATLD2, proliferating cell nuclear antigen
External IDs	OMIM: 176740 MGI: 97503 HomoloGene: 1945 GeneCards: PCNA
Gene location (Human)
Chr.	Chromosome 20 (human)
End	5,126,626 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	132,095,234 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; spongy bone; ; rectum; ; appendix; ; bone marrow; ; cavity of mouth; ; sperm; ; retinal pigment epithelium;
	Top expressed in
	thymus; ; yolk sac; ; bone marrow; ; secondary oocyte; ; ileum; ; spleen; ; ovary; ; stomach; ; uterus; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MutLalpha complex binding; identical protein binding; enzyme binding; receptor tyrosine kinase binding; DNA binding; DNA polymerase binding; damaged DNA binding; dinucleotide insertion or deletion binding; protein binding; chromatin binding; histone acetyltransferase binding; estrogen receptor binding; purine-specific mismatch base pair DNA N-glycosylase activity; DNA polymerase processivity factor activity;
Cellular component	nucleus; replisome; nucleoplasm; extracellular exosome; DNA replication factor C complex; centrosome; PCNA complex; nuclear replication fork; PCNA-p21 complex; replication fork; nuclear body; chromatin;
Biological process	replication fork processing; translesion synthesis; DNA replication; nucleotide-excision repair, DNA gap filling; protein sumoylation; regulation of DNA replication; transcription-coupled nucleotide-excision repair; positive regulation of deoxyribonuclease activity; nucleotide-excision repair, DNA incision; error-free translesion synthesis; positive regulation of DNA repair; regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of DNA replication; response to lipid; heart development; DNA mismatch repair; cellular response to DNA damage stimulus; mitotic telomere maintenance via semi-conservative replication; epithelial cell differentiation; response to cadmium ion; cell population proliferation; telomere maintenance; error-prone translesion synthesis; cellular response to UV; estrous cycle; cellular response to hydrogen peroxide; response to dexamethasone; nucleotide-excision repair, DNA incision, 5'-to lesion; liver regeneration; response to estradiol; response to oxidative stress; DNA repair; response to L-glutamate; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA ligation; leading strand elongation; protein ubiquitination; telomere maintenance via semi-conservative replication; viral process;
	Sources:Amigo / QuickGO
Orthologs
	5111
	18538
	ENSG00000132646
	ENSMUSG00000027342
	P12004
	P17918
	NM_182649; NM_002592
	NM_011045
	NP_002583; NP_872590
	NP_035175
	Wikidata
View/Edit Human	View/Edit Mouse

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.

Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide (PIP) box and AlkB homologue 2 PCNA interacting motif (APIM). Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress.

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