PAS domain
A Per-Arnt-Sim (PAS) domain is a protein domain found in all kingdoms of life. Generally, the PAS domain acts as a molecular sensor, whereby small molecules and other proteins associate via binding of the PAS domain. Due to this sensing capability, the PAS domain has been shown as the key structural motif involved in protein-protein interactions of the circadian clock, and it is also a common motif found in signaling proteins, where it functions as a signaling sensor.
PAS fold | |||||||||||
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Crystallographic structure of the PAS domain of the bacterial oxygen sensor protein fixL. The protein is depicted as a rainbow colored cartoon (N-terminus = blue, C-terminus = red) while the heme ligand is shown as sticks (carbon = white, nitrogen = blue, oxygen = red, iron = orange). | |||||||||||
Identifiers | |||||||||||
Symbol | PAS | ||||||||||
Pfam | PF00989 | ||||||||||
InterPro | IPR013767 | ||||||||||
SMART | PAS | ||||||||||
PROSITE | PDOC50112 | ||||||||||
SCOP2 | 2phy / SCOPe / SUPFAM | ||||||||||
CDD | cd00130 | ||||||||||
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