PARP1

PARP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UK0, 1UK1, 1WOK, 2COK, 2CR9, 2CS2, 2DMJ, 2JVN, 2L30, 2L31, 2RCW, 2RD6, 2RIQ, 3GJW, 3GN7, 3L3L, 3L3M, 3OD8, 3ODA, 3ODC, 3ODE, 4AV1, 4DQY, 4GV7, 4HHY, 4HHZ, 4L6S, 4OPX, 4OQA, 4OQB, 4PJT, 4UND, 4ZZZ, 5A00, 4R5W, 4R6E, 4UXB, 2N8A, 4XHU, 4RV6, 5HA9, 5DS3
Identifiers
Aliases	PARP1, ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly(ADP-ribose) polymerase 1, Poly-PARP, PARS
External IDs	OMIM: 173870 MGI: 1340806 HomoloGene: 1222 GeneCards: PARP1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	226,408,154 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,428,819 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; lymph node; ; middle frontal gyrus; ; appendix; ; corpus callosum; ; amygdala; ; islet of Langerhans; ; left ventricle; ; spleen; ; prefrontal cortex;
	Top expressed in
	otic placode; ; saccule; ; abdominal wall; ; external carotid artery; ; yolk sac; ; medullary collecting duct; ; Paneth cell; ; internal carotid artery; ; spermatocyte; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; R-SMAD binding; DNA ligase (ATP) activity; protein N-terminus binding; glycosyltransferase activity; NAD binding; zinc ion binding; transcription factor binding; histone deacetylase binding; metal ion binding; protein binding; identical protein binding; protein kinase binding; estrogen receptor binding; enzyme binding; SMAD binding; RNA binding; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; NAD DNA ADP-ribosyltransferase activity;
Cellular component	nuclear envelope; membrane; transcription regulator complex; nucleoplasm; nucleolus; mitochondrion; nucleus; protein-DNA complex; cytoplasm; protein-containing complex; site of double-strand break; site of DNA damage; chromosome;
Biological process	positive regulation of transcription regulatory region DNA binding; lagging strand elongation; regulation of transcription, DNA-templated; mitochondrial DNA metabolic process; mitochondrial DNA repair; nucleotide-excision repair, DNA damage recognition; mitochondrion organization; signal transduction involved in regulation of gene expression; protein autoprocessing; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; macrophage differentiation; cellular response to DNA damage stimulus; positive regulation of cardiac muscle hypertrophy; global genome nucleotide-excision repair; double-strand break repair via homologous recombination; protein modification process; cellular response to insulin stimulus; negative regulation of telomere maintenance via telomere lengthening; protein poly-ADP-ribosylation; cellular response to oxidative stress; DNA ligation involved in DNA repair; nucleotide-excision repair, DNA incision; DNA repair; positive regulation of SMAD protein signal transduction; nucleotide-excision repair, preincision complex assembly; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; cellular response to zinc ion; regulation of SMAD protein complex assembly; cellular response to amyloid-beta; regulation of DNA methylation; positive regulation of mitochondrial depolarization; nucleotide-excision repair, DNA incision, 3'-to lesion; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of protein localization to nucleus; nucleotide-excision repair, DNA incision, 5'-to lesion; cellular response to transforming growth factor beta stimulus; double-strand break repair; transcription, DNA-templated; positive regulation of myofibroblast differentiation; nucleotide-excision repair, DNA duplex unwinding; positive regulation of neuron death; response to aldosterone; transforming growth factor beta receptor signaling pathway; nucleotide-excision repair, preincision complex stabilization; response to gamma radiation; regulation of catalytic activity; ATP generation from poly-ADP-D-ribose; negative regulation of ATP biosynthetic process; telomere maintenance; protein ADP-ribosylation; peptidyl-serine ADP-ribosylation; positive regulation of transcription by RNA polymerase II; apoptotic process; positive regulation of single strand break repair; peptidyl-glutamic acid poly-ADP-ribosylation; DNA ADP-ribosylation; cellular response to UV; protein auto-ADP-ribosylation; positive regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	142
	11545
	ENSG00000143799
	ENSMUSG00000026496
	P09874
	P11103
	NM_001618
	NM_007415
	NP_001609; NP_001609.2
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD⁺ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. It is the most abundant of the PARP family of enzymes, accounting for 90% of the NAD+ used by the family. PARP1 is mostly present in cell nucleus, but cytosolic fraction of this protein was also reported.

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