PAPSS1

PAPSS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X6V, 1XJQ, 1XNJ, 2OFW, 2OFX, 2PEY, 2PEZ, 2QJF
Identifiers
Aliases	PAPSS1, ATPSK1, PAPSS, SK1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
External IDs	OMIM: 603262 MGI: 1330587 HomoloGene: 81740 GeneCards: PAPSS1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	107,720,234 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	131,349,432 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; secondary oocyte; ; pons; ; bronchial epithelial cell; ; subthalamic nucleus; ; pylorus; ; corpus callosum; ; endometrium; ; superior vestibular nucleus; ; Brodmann area 46;
	Top expressed in
	left colon; ; submandibular gland; ; lacrimal gland; ; medullary collecting duct; ; ileum; ; utricle; ; optic nerve; ; endocardial cushion; ; ventral tegmental area; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; catalytic activity; ATP binding; kinase activity; sulfate adenylyltransferase (ATP) activity; protein homodimerization activity; adenylylsulfate kinase activity;
Cellular component	cytosol;
Biological process	skeletal system development; metabolism; phosphorylation; sulfate assimilation; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9061
	23971
	ENSG00000138801
	ENSMUSG00000028032
	O43252
	Q60967
	NM_005443
	NM_001289477; NM_001289478; NM_001289479; NM_011863
	NP_005434
	NP_001276406; NP_001276407; NP_001276408; NP_035993
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM]

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