PAPOLG

PAPOLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LT6
Identifiers
Aliases	PAPOLG, poly(A) polymerase gamma
External IDs	OMIM: 616865 MGI: 2442119 HomoloGene: 56959 GeneCards: PAPOLG
Gene location (Human)
Chr.	Chromosome 2 (human)
End	60,802,086 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	23,845,253 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; ganglionic eminence; ; tibia; ; thyroid gland; ; secondary oocyte; ; blood; ; palpebral conjunctiva; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	secondary oocyte; ; atrioventricular valve; ; endocardial cushion; ; medullary collecting duct; ; maxillary prominence; ; pineal gland; ; medial ganglionic eminence; ; hand; ; trigeminal ganglion; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; polynucleotide adenylyltransferase activity; ATP binding; metal ion binding; RNA binding;
Cellular component	membrane; nucleus; nucleoplasm; cytosol; nuclear body;
Biological process	mRNA polyadenylation; mRNA processing; RNA polyadenylation; RNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	64895
	216578
	ENSG00000115421
	ENSMUSG00000020273
	Q9BWT3
	Q6PCL9
	NM_022894
	NM_172555
	NP_075045
	NP_766143
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(A) polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene.

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.

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