PAPOLA

PAPOLA
Identifiers
Aliases	PAPOLA, PAP, poly(A) polymerase alpha, PAP-alpha
External IDs	OMIM: 605553 MGI: 109301 HomoloGene: 23389 GeneCards: PAPOLA
Gene location (Human)
Chr.	Chromosome 14 (human)
End	96,567,116 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	105,805,203 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; bone marrow cells; ; body of pancreas; ; endometrium; ; jejunal mucosa; ; islet of Langerhans; ; rectum; ; lymph node; ; cardia;
	Top expressed in
	yolk sac; ; abdominal wall; ; dermis; ; islet of Langerhans; ; spermatid; ; atrioventricular valve; ; seminal vesicula; ; ganglionic eminence; ; morula; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; manganese ion binding; metal ion binding; protein binding; RNA binding; ATP binding; magnesium ion binding; polynucleotide adenylyltransferase activity;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA 3'-end processing; mRNA processing; mRNA polyadenylation; mRNA 3'-end processing; regulation of mRNA 3'-end processing; RNA polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	10914
	18789
	ENSG00000090060
	ENSMUSG00000021111
	P51003
	Q61183
NM_001252006; NM_001252007; NM_001293627; NM_001293628; NM_001293632;
	NM_032632; NM_001363662; NM_001363664; NM_001363665; NM_001363666
	NM_011112; NM_001347440
NP_001238935; NP_001238936; NP_001280556; NP_001280557; NP_001280561;
	NP_116021; NP_001350591; NP_001350593; NP_001350594; NP_001350595
	NP_001334369; NP_035242
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex. This complex polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, binds with and stimulates POPOLA's Polynucleotide adenylyltransferase activity, and thereby adds adenylyl residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias.

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